DESDE tends to indicate the origin of an action, especially if a destination isn’t mentioned:
Fuimos en coche desde/de Madrid hasta/a Valencia (We drove from Madrid to Valencia).
Me llamó desde Nueva York (He called me from New York).
Corrió desde la playa (He ran from the beach).
Desde is also used with several other prepositions, creating phrases that also indicate motion. Below you can see just a few:
– Desde abajo (From below)
– Desde arriba (From above)
– Desde dentro (From within)
– Desde aquí (From here)